CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P

Product Name: CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
CAS No.: 215923-54-9
Chemical Name: CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
Synonyms: GR 87;BDP 17;CX-546;BDP-17,CX546,GR87;CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P;1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine;1-(2,3-Dihydro-1,4-benzodioxin-6-ylcarbonyl)piperidine;(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone;2,3-dihydro-1,4-benzodioxin-6-yl(piperidin-1-yl)methanone;Methanone,(2,3-dihydro-1,4-benzodioxin-6-yl)-1-piperidinyl-
CBNumber: CB7972429
Molecular Formula: C14H17NO3
Formula Weight: 247.29
MOL File: 215923-54-9.mol

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CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Property

Melting point:: 71-73°C
Boiling point:: 422.8±44.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥10mg/mL
pka: -1.08±0.20(Predicted)
form: solid
color: white to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C271
Product name: CX546
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $277
Updated: 2024/03/01

Sigma-Aldrich

Product number: C271
Product name: CX546
Purity: ≥98% (HPLC), solid
Packaging: 50mg
Price: $395.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.05016
Product name: CX546 - CAS 215923-54-9 - Calbiochem
Packaging: 10MG
Price: $188
Updated: 2022/05/15

Tocris

Product number: 2980
Product name: CX546
Purity: ≥99%(HPLC)
Packaging: 10
Price: $150
Updated: 2021/12/16

Tocris

Product number: 2980
Product name: CX546
Purity: ≥99%(HPLC)
Packaging: 50
Price: $585
Updated: 2021/12/16

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CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Chemical Properties,Usage,Production

Uses

It is one of a series of AMPA modulators matergic AMPA receptors.

Uses

CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.

General Description

CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.

Biological Activity

AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats.

Biochem/physiol Actions

CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI)?in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.

storage

Store at +4°C

CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Preparation Products And Raw materials

Raw materials

Preparation Products

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CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Suppliers

Canada 1 China 67 India 1 Switzerland 1 United Kingdom 2 United States 15 Global 87

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View Lastest Price from CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P manufacturers

Career Henan Chemical Co

Product: CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P 215923-54-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-02

215923-54-9, CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)PRelated Search:

3-Methylpiperidin-3-ol HCl 4-ETHOXY-N,N-DIETHYLBENZAMIDE 3-ethoxy-N,N-diethyl-4-hydroxybenzamide CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P CHEMBRDG-BB 5762406

1-(2,3-Dihydro-1,4-benzodioxin-6-ylcarbonyl)piperidine

1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine

CX-546

BDP-17,CX546,GR87

Methanone,(2,3-dihydro-1,4-benzodioxin-6-yl)-1-piperidinyl-

CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P

(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)(piperidin-1-yl)Methanone

(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone

BDP 17

GR 87

(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylMethanone CX 546

2,3-dihydro-1,4-benzodioxin-6-yl(piperidin-1-yl)methanone

inhibit,CX-546,Autophagy,CX546,Inhibitor,CX 546,Ionotropic glutamate receptors,iGluR

215923-54-9

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

AMPA receptor potentiator which is specifically bound to agonist bound non-desensitized receptors.